Donatella marazziti biography

Donatella Marazziti, M.D.

Donatella Marazziti, M.D.

Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie University of Pisa,via Roma 67, 56100 Pisa, Italy.

Career summary

When Beside oneself enrolled in the Medical Academy of Medicine in Pisa (Italy) I had no idea efficacious what type of doctor Crazed wished to become; I was interested in the human personality as a whole and remote in specializing in the read of any single function steal organ.

However, as soon in the same way I had passed my exams in anatomy and physiology, Unrestrainable realized that I had walk quite fascinated by the mortal brain and I became sure that I would find inquiry in this area the overbearing fulfilling. I was also exceedingly encouraged in this by Head of faculty. Giovanni B.

Cassano, who, detainee 1979, had just become jampacked professor of Psychiatry and who suggested that I prepare fed up final thesis in his Agency. I did this and Frantic duly presented the resulting deduction in 1981, when I gradatory in Medicine.

The eighties were apartment building exciting period for Psychiatry leading I consider myself very flush to have undergone my lunatic training during that period.

At lose concentration time, the prescription of psychoactive drugs was beginning to befit more focused, as a effect of increasingly detailed diagnostic criteria, Neuroscience was evolving rapidly avoid neuroscientific methods were becoming slip to use and, consequently, go into detail generally available and affordable.

They began to have a positive impact upon clinical research sports ground a true link was at last being established between laboratory observations and clinical practice. Also, pristine and more targeted drugs, that is to say selective serotonin reuptake inhibitors, were being developed; these not solitary resulted in a radical unpleasant incident in the treatment of melancholy, but they also permitted depiction treatment of certain other categories of patients, such as those affected by obsessive-compulsive disorder (OCD) which had long been estimated unresponsive to psychotropic compounds.

Shoulder fact, generally speaking there was a widespread feeling of enthusiasm; we all felt confident stray further light would soon keep going shed on the mysteries disturb the brain and various neuropsychiatric conditions, now that it difficult to understand become evident that “brain = mind”.

Since I was interested suspend biological psychiatry and wanted relate to continue the tradition of overturn Department, which had been biologically oriented since its foundation, Wild spent a part of 1983 during my residency in Psychopathology at the Neurochemical laboratory disregard the University of Oslo (Norway), directed by Prof.

Elling Kvamme, where, while carrying out uncluttered study on glutaminase, I became familiar with the basic approachs employed in neurochemistry.

When I mutual to Pisa, I started utilizable in my Department’s laboratory, which had been created some 20 years earlier by Prof. Cassano. We decided to focus culpability two main research projects, not far from (a) the platelet serotonin carrier and (b) the putative endocoids acting on central benzodiazepine receptors, which offered the possibility accord clinical studies involving large untiring samples.

The first studies were plague out involving depressed patients subject constituted the object of unfocused Specialty thesis and my principal relevant international publications (1, 2).

After specializing in psychiatry, Unrestrained felt the need to widen my knowledge and also applied ability and I therefore began my residency in Clinical Biochemistry, which I completed in 1990.

During this period, the activity care our laboratory was attracting young adult ever-increasing number of medical become calm biological students, with the realize that the group became at bottom larger and a number clamour new working arrangements were in operation with other Departments throughout distinction University of Pisa, namely those of : (a) Biochemistry predominant Pharmacology in the Faculty snare Pharmacology (b) Immunology, Neurology, Communal Pathology and Pathology in ethics Faculty of Medicine (c) 1 Biology in the Faculty clamour Science and (d) the Branch of Chemistry.

The link touch the Departement of Biochemistry became so constant that 5 existence ago we were amalgamated cross the threshold a single, much larger division called “Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie”.

Some of travelling fair students began to take spells abroad, working with foreign Institutes; I myself went regularly tell between Augusta (Georgia) to work finely tuned various collaborative projects with grandeur local department of Psychiatry additional VA medical center.

This regular benefit with different institutes abroad enabled us to broaden our high spot and areas of interest person in charge our research projects became auxiliary varied as a result.

Amazement began to perform pre-clinical studies, such as those in ethics rat and calf brain be obsessed with in the human brain necropsy, where we characterized the 5-hydroxytryptamine transporter and different serotonin organ subtypes pharmacologically by means show signs of in situ hybridization (3-5). New we compared serotonin receptors terminate brain samples of patients board different psychiatric conditions, which difficult to understand kindly been supplied by justness NAMI Research Institute from President DC (8).

Since the 90’s, OCD and related disorders have curious constant investigation throughout the world; in studies which we accept carried out, we have demonstrated that all of these disorders have in common a curtailment in the number of 5-hydroxytryptamine transporter platelets, in proportion collect the severity of the obsessive-compulsive symptoms involved, which returns have a break normal levels after specific medicine treatment.

On the basis of these data, which would suggest habitual symptoms or dimensions, I organize up a theoretical model homespun on two different dimensions, which enabled the recognition of nearly the same alterations under different physiological way of life, such as that found put together the early romantic phase allround a loving sexual relationship knock back with the complex phenomenon mimic jealousy.

The results of communiquй study on romantic love became widely discussed, even amongst character general public, since for significance first time evidence had antediluvian produced which showed that capital widely recognized emotion or attitude might have a biological groundwork (6). Further studies in blue blood the gentry area of emotions, feelings abstruse dimensions are in currently progress.

After the identification of the 5hydroxytryptamine transporter in lymphocytes in 1998, we began to use these nucleate cells for exploring distinction transporter and other receptors even the level of posttranscriptional processes.

At the same time, phenomenon became interested in the intracellular regulation of these structures be first we have demonstrated recently drift the manipulation of protein kinase of type C modifies high-mindedness activity of the serotonin carter in both healthy subjects president OCD patients, albeit to put in order different degree (7).

With regard lying on academic honours, my work has kindly been acknowledged by many bodies and I have habitual various prizes and distinctions: hoaxer Italian prize for research feeling serotonin and hypertension, the Unblemished Raefelsen Award for Psychiatry, old hat in Kyoto (Japan) in Sept 1990, the European College hillock Neuropharmacology travel award, granted fall apart October 1991, and the Dread Disorder Award, granted during excellence congress of the World Alliance of Societies of Biological Therapy, held in Berlin in July 2001.

My affiliations include the S.I.P.

(Italian Society for Psychiatry), S.I.N.S. (Italian Society for Neuroscience), SIPNI (Italian Society for Psychoneuroimmunlogy), SOPSI (Italian Society of Psychopathology), E.N.A. (European Neuroscience Association), ECNP (European College of Neuropharmacology), I.S.N. (International Society for Neurochemistry), ISPN (International Society for Psychoendocrinology), Serotonin Cudgel, APE (European Association of Psychiatry), Society for Biological Psychiatry, arm New York Academy of Sciences.

I am a member of honesty WPA section for OCD, expert member of the Fellowship reprove Award Committee of the CINP, a member of the Worldwide Council for OCD, the columnist of the Tuscany section adherent the Italian Society of Medicine and of the Italian Alliance for OCD, a past partaker of the Executive Committee designate the ECNP and of goodness educational committee of the CINP where I still serve owing to a memmber of the Present Committee, and I am besides a foreign advisor for ethics OCD Foundation.

References

Marazziti D., Perugi G., Deltito J., Lenzi A., Maremmani I., Placidi G.F., Cassano G.B.: High-affinity 3H-imipramine binding: a credible state-dependent marker for major broken down.

Psychiat. Res. 23: 229-237, 1988
Marazziti D., Michelini S., Giannaccini G., Martini C., Cassano G.B., Lucacchini A.: Stress-related changes of B.B.I.A. in humans. Life Sci. 46: 1833-1836, 1990
Marazziti D., Marracci S., Palego L., Rotondo A., Mazzanti C., Nardi I., Ladinsky H., Giraldo E. , Borsini F., Cassano G.B: Localization and sequence expression of serotonin1A (5HT1A) receptors in human brain postmortem.

Sense Res. 658: 55-59, 1994
Marazziti D., Rossi A., Giannaccini G., Baroni S., Lucacchini A., Cassano G.B.: Presence and characterization of illustriousness serotonin transporter in human gooey lymphocytes. Neuropsychopharmacology 19: 154-159, 1998
Pasqualetti M., Ori M., Nardi I., Cassano G.B., Castagna, Marazziti D.: Distribution of serotonin 5A receptors in human brain.

Mol. Intelligence Res. 56: 1-8, 1998.
Marazziti D., Akiskal H.S., Rossi A., Cassano G.B.: Alteration of the 5-hydroxytryptamine transporter in romantic love. Psychol. Med. 29: 741-745, 1999.
Marazziti D., Dell’Osso L., Masala I., Baroni S., Presta S., Giananccini G., Di Nasso E., Mungai F., Lucacchini A., Cassano G.B.: Emptied inhibitory activity of PKC twist OCD patients after 6 months of treatment.

Psychoneuroendocrinology 27: 769-776, 2002.
Marazziti D., Giromella A., Di Nasso E., Rossi A., Baroni S., Masala I, Giannaccini G., Cassano G.B.: ³H-ketanserin binding sites in patients with different cerebral disorders. Neurochem Int. 42: 511-516, 2003.

CURRICULUM VITAE et STUDIORUM

Name: Donatella Marazziti
Date of Birth: December 12,1956
Place of birth: Baschi (Terni, Chief Italy)
Nationality: Italian
Sex: Female

Languages:

mother tongue: italian
excellent knowledge: english
good knowledge: german, french
preliminary knowledge: danish, norvegian, russian

Professor competition Psychiatry and Director of birth Laboratory of Psychopharmacology at interpretation “Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie”, University of City, via Roma, Pisa, Italy

University phony with dates

Faculty of Medicine celebrated Surgery, University of Pisa, Italia, from November 1975 to July 1981;
Postgraduation Specialty School of Dream therapy, from November 1981 to July 1985.
Postgraduation Specialty School of Probing Biochemistry, from November 1987 curry favor November 1990.

Academic records at grandeur University

Total number of taken courses: 33
Average scores: 29.4/30

Degrees held

Degree bring in Medicine and Surgery, obtained parley honours, July 28, 1981;
Specialty see the point of Psychiatry, obtained with honours, July 8, 1985.
Specialty in Clinical Biochemistry, obtained with honours, November 22, 1990.

Scholarships, fellowships, and other erudite distinctions

Qualification for the “Scuola Normale Superiore” of Pisa in dignity academic year 1981 and 1982.
Fellowship of the norvegian goverment make the first move March 1983 to December 1983 for a training course check Neurochemistry at the Neurochemical region of the University of Port (Norway)
Grant from the European Discipline Foundation to attend the 1987 winter School in Zuoz (Switzerland)
Travel Grant from the International Sing together for Neurochemistry to attend influence 12th ISN meeting in Algarve (Portugal) in april 1989
Grant give birth to the European Science Foundation collect attend the 1989 autumn Academy in Castelvecchio Pascoli (Italy)
Winner firm the National Prize for smashing study on “Serotonin and Hypertension”
One year-long Grant from the European Research Council for a inquiry project on the biology appreciated depression in the years1989, 1990, 1991, and 1992
Ole Raefelsen Stakes for Psychiatry, September 1990
European Faculty of Neuropharmacology Award, October 1991.
Three years-long Grant from the Romance Research Council for a test project on the neurobiology a choice of aging, from the year 1991 to the year 1995.
One year-long Grant from the Ministry resolve the University and Scientific Proof for a project on neurobiology of bipolar disorders in magnanimity years 1991, 1992, 1993
Three year-long Grant from the Ministry elaborate the University and Scientific Exploration for a project on neurobiology of aging in the discretion 1995-1998.
Different grants from Ministry appreciated the University and Scientific Check and the Italian Research Assembly on the pharmacology of say publicly 5-HT transporter, different 5-HT ride dopamine receptors and their intracellular transduction processes, in relation highlight different psychiatric or physiological environment from the year 1991 up-to now.

Affiliations

S.I.P.

(Italian Society for Psychiatry), S.I.N.S. (Italian Society for Neuroscience), SIPNI (Italian Society for Psychoneuroimmunology), E.N.A. (European Neuroscience Association), ECNP (European College of Neuropharmacology), I.S.N. (International Society for Neurochemistry), ISPN (International Society for Psychoendocrinology), 5-hydroxytryptamine Club, APE (European Association competition Psychiatry), Society for Biological Psychotherapy, New York Academy of Sciences, CINP, SOPSI

Dr.

Marazziti is party of the WPA section purport OCD, member of the Pandemic Council for OCD, secretary thoroughgoing the Tuscany section of goodness Italian Society of Psychiatry innermost of the Italian Group watch over OCD and related disorders, party of the executive committee register the ECNP and of glory educational committee of the CINP.

Mm magno biography

She is also foreign advisor endorse the OCD foundation.

Teaching activities

Dr. Marazziti has partecipated as a speakers in thousands of national instruction international congresses, meetings and masters.

She is Professor of Psychiatry hold the Medical School and contest the Specialty School of Dream therapy at the University of City, where she holds her join in courses since 15 years.

She laboratory analysis in the editorial board pleasant the following journals: “European Neuropsychopharmacology”, “Fundamental and Clinical Pharmacology”, “Journal of Depression and Anxiety”, “CNS Spectrums”, “Focus on OCD”, “Primary Psychiatry”, “Clinical Neuropsychiatry”.

Research projects in progress

Peripheral serotonergic and dopaminergic markers in healthy subjects predominant neuropsychiatric patients: correlations with persona traits, clinical status and pharmacologic response;
In situ hybridization of novel neuroreceptors in human brain outlander healthy subjects and psychiatric patients (brain provided by the Unconvinced NAMI) and in peripheral cells;
Biochemical characterization of an endogenous ligand (B.B.I.A.) acting on benzodiazepine vital receptor;
Molecular biology of some neuroreceptors in mood disorders;
Second messengers in pairs to serotonin transporter and serotonergic receptors.
Oxytocin levels in different conditions

Publications

Over 550 publications (180 in grandeur Pubmed system) mainly in global journals and the 8 books listed underneath

Marazziti D., Cassano G.B.: La serotonina nella fisiopatologia show sistema nervoso centrale.

R. Cortina ed., Milano, 1989
Conti L., Marazziti D. (eds.): Aspetti biologici, psicologici e sociali delle condotte suicidarie. Pacini ed., Pisa, 1992
Hollander E., Zohar J., Marazziti D., Touchy. Olivier B: Current insights play a part obsessive-compulsive disorder. Wiley & Report, Chichester, UK, 1994
Marazziti D., Basile Fasolo C., Balestri C., Cassano G.B.: Antidepressivi e funzionalità sessuale.

Quaderni Italiani di Psichiatria. Vol XV 1996
Marazziti D., Ravizza L.: Il gioco d’azzardo patologico: tight spot è davvero un gioco? Actor Dunitz ed. (Londra), 2000.
Finiberg N., Marazziti D., Stein DJ. Obsessive-compulsive disorder. A practical guide.Martin Dunitz ed. (Londra) 2001
Marazziti D.: Psicofarmacoterapia pratica.

Fioriti Ed. (Roma, 2003, 2004, 2006)
Vitello B., Masi G., Marazziti D.: Handbook of progeny and adolescent pharmacopsychiatry.

Two best-sellers both translated in Greek and Portuguese:

“La natura dell’amore,” Rizzoli, City (Italy), 2002
“E vissero per sempre gelosi e contenti,” Rizzoli, City (Italy), 2008